Assessment of insulin resistance and lipid bound sialic acid in alcoholic liver disease.

ABSTRACT

Background: Even though alcoholic liver disease is common disease in India, there are only limited reports about insulin resistance and no reports about lipid bound sialic acid in these cases. The present study was designed to evaluate insulin resistance and lipid bound sialic acid levels in patients with alcoholic liver disease Materials and methods: 50 alcohol liver disease cases groups [Fatty liver (n=18), alcoholic hepatitis (n=19) and cirrhosis (n=13)] and 38 controls were enrolled in the study. Fasting insulin, lipid bound sialic acid and liver function test parameters were analyzed in both the groups Results: Insulin, homeostasis model of insulin resistance and lipid bound sialic acid were significantly increased in alcohol liver disease cases compared to controls. Both insulin and insulin resistance were higher in alcoholic hepatitis and cirrhosis group compared to fatty liver group and controls Conclusion: To conclude, the present study demonstrates increased insulin resistance and lipid bound sialic acid in patients with ALD.