Spectral and electrochemical studies of fluvoxamine.
Article
in English
| IMSEAR
| ID: sea-163689
ABSTRACT
The spectral and voltammetric behavior of fluvoxamine (1) in aqueous buffers of varied pH is presented. Spectrophotometry, cyclic voltammetry, differential pulse polarography and coulometry were utilized to study its proton and electron transfer characteristics. Relevant thermodynamic and electrochemical data such as charge transfer coefficient (αna), heterogeneous forward rate constant (k0 f,h), etc, have been evaluated. An excellent electroanalytical assaying of 1 has been developed in differential pulse polarography at pH = 3. Molecular modeling on various acid-base conjugates of 1 and their several conformers has been carried out to arrive at the thermodynamic and conformational issues to correlate to the spectral and electrochemical observations.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Prognostic study
Language:
English
Year:
2012
Type:
Article
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