Identification of T-Cell epitopes in structural proteins of tick borne encephalitis virus for vaccine development.
Article
in English
| IMSEAR
| ID: sea-163720
ABSTRACT
Tickborne encephalitis (TBE) is a human viral infectious disease caused by tickborne encephalitis virus (TBEV). It is transmitted by the bite of an infected tick and also initiated the swelling of brain (encephalitis) and spinal cord. There is a pressing need to develop potent and sufficient amount of drugs and vaccines for control of TBE. We have selected the structural proteins such as anchored core protein C, core protein C, premembrane, matrix and envelope proteins of TBEV for identification of T-cell epitopes using immunoinformatics tools. These epitopes were showed the highest binding affinity with major histocompatibility complex (MHC) class I and II molecules. These finding may be used as an immunodiagnostic agent and also development of peptide based novel vaccines.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Diagnostic study
/
Prognostic study
Language:
English
Year:
2012
Type:
Article
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