Facile synthesis of chelating bis ligands: spectroscopic, physicochemical and biological studies.

ABSTRACT

Seven bis-ligands of carbamides were synthesized and characterized on the basis of elemental analysis, Infrared spectroscopy, 1H NMR, mass spectra and UV-Visible studies. These bis-ligands were synthesized by condensation method, of acidic dichloride with 4-methoxyphenylcarbamide (4-MPC) in stoichiometric ratio of 12 respectively. It were found that, the behaviour of bis-ligands acting as chelating agents (chelators), therefore these were comparatively interpreted on the basis of physicochemical properties such as viscosity, surface tension, conductivity, pH and solubility. The antimicrobial activities of chelating ligands also have been studied. The results were revealing that, the activities of newly synthesized chelating ligands were found to be higher than its parent’s compound. The aromatic chelating compounds shows more activity in all physicochemical properties as compare to aliphatic chelators. The nanoparticle sizes of chelating ligands were significantly identified by scanning electron microscopy (SEM) and morphological result of each chelating compound were found totally different.