Phytochemical screening and insilico approach for the identification of anti stress compounds from medicinal plants.

ABSTRACT

In India, many forms of alternative medicines are available for those who cannot be helped by conventional medicine. Ayurvedha and Herbal medicine are two important forms of alternative medicine that is widely available in India. This work was mainly concerned with the identification of the therapeutic properties of Indian medicinal plant extracts. Everyone knows that medicinal plants have disease curing properties and this is due to the compounds presents in the extracts used for the treatment. So we identified the compounds of different medicinal plants like Celastrus paniculatus, Withania somnifera, Convolvulus pluricaulis, Rauvoifia Serpentina etc which are used as medicine for Stress in Ayurvedha from previous literature. After identification using chemsketch software these compounds were designed and screened for antistress property. The proteins responsible for stress in Homo sapiens were collected using Protein databank (PDB). Active sites were identified and used for docking with the compounds. Then the compounds were docked to the Calcium channel in order find better inhibitor. Among 33 compounds 10 compounds showed best docking results for each protein. ADMET studies were performed using Molinspiration and OSIRIS server.