The Protective Effect of Coriandium sativum Extract on Hepato-renal Toxicity Induced in Irradiated Rats.
European J Med Plants
;
2014 Feb; 4(2): 196-205
Article
in English
| IMSEAR
| ID: sea-164083
ABSTRACT
Aim:
The aim of this study was to examine the effect of ethanolic extract of coriander leaves as a potent in vivo antioxidant agent in an effort of finding possible sources of antioxidants for future use in food and pharmaceutical formulations. StudyDesign:
Randomized controlled experiment. Place and Duration of Study Experimental Animal Unit, Drug Radiation Research Department, National Center for Radiation Research and Technology, Cairo Egypt.Methodology:
Antioxidant activity of ethanol extract of coriander leaves was estimated by oxidative stress induced by radiation exposure with the dose of 4 Gy, Silymarin was used as a reference antioxidant drug in female albino rat.Results:
Results of experiment revealed that radiation exposure caused a significant increase in serum caspase3 (0.870± 0.086), alanine transaminase (ALT) activity (24.43± 5.02) as well as urea (42.53± 6.11) and creatinine (0.865± 0.064) levels with an increase in liver and kidney lipid peroxidation (MDA) (307.0± 29.22 & 285.5± 48.93) respectively, while decrease in serum albumin (3.003± 0.355), protein (8.66± 0.436) as well as glutathione (GSH) contents of liver and kidney tissues (63.24± 12.19 & 17.38± 1.414) were estimated respectively. In addition serum globuline level and albumin /globuline ratio showed no significant changes. On the other hand, the administration of coriander (600 mg/kg bw) and silymarin (70 mg/kg bw) pre-treatment effectively prevented these alterations and maintained the antioxidant status.Conclusion:
Data from present results revealed that Coriandum Sativum act as an antioxidant agent due to its free radical scavenging and cytoprotective activity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Controlled clinical trial
Language:
English
Journal:
European J Med Plants
Year:
2014
Type:
Article
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