In-vivo evaluation of potential toxicity of vanadium pentoxide in male wistar rats.

ABSTRACT

Diabetes is characterized by derangements in carbohydrates, protein and fat metabolism caused by the complete or relative insufficiency of insulin secretion. The decreased oxidative stress in diabetes includes the autoxidation of glucose and non enzymaticglycation and also changes in the antioxidants defense systems. As the diabetes is lowered in human the pharmacological effects of a drug becomes toxic. Our aim was to evaluate the invivo effect of the anti diabetic compound Vanadium in non- diabetic rat models. The oral administration of Vanadium peroxide shows significant changes in the Cholesterol and TG with organ morphology and enhancement in clinical and experimental parameters.Vanadium is an important environmental and industrial pollutant. It is a dietary micronutrient and it has been recently considered as a pharmacological agent. Vanadium compounds have a major role in cellular regulation, with profound effects on enzymes of plasma membrane. Vanadium is one of the abundance trace elements widely distributed in the environment. It is used in steel and chemical industries, and is a containment of many ores, coals, and petroleum oils the manufacture of pigments, in photography and in insecticides. It is been used medicinally as anticeptic, spirochetocide, antituberculotic and antianemic agents and general tonic.