Superoxide anions mediate proliferative response in cardiac fibroblasts.
Article
in English
| IMSEAR
| ID: sea-16443
ABSTRACT
The study was undertaken to examine whether superoxide anions mediate a proliferative response in cardiac fibroblasts. Cardiac fibroblasts isolated from newborn Wistar rats were exposed to superoxide anion generating system (hypoxanthine + xanthine oxidase) and its effect on cell growth was assessed. A stimulatory response on fibroblast proliferation was observed. The proportion of proliferating cells increased within 3 h of treatment compared to the control and the cell density after 96 h of exposure remained significantly high (P < 0.0005). Inclusion of antioxidants neutralised the stimulatory response, fortifying the role of superoxide anions in cell proliferation. This observation indicates that superoxide anions can mediate a fibrotic reaction in the cardiac tissue.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Cell Division
/
Cells, Cultured
/
Rats, Wistar
/
Superoxides
/
Proliferating Cell Nuclear Antigen
/
Fibroblasts
/
Animals
/
Myocardium
Language:
English
Year:
2000
Type:
Article
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