Vorapaxar, a novel oral antiplatelet drug.
Article
in English
| IMSEAR
| ID: sea-165025
ABSTRACT
Vorapaxor is first in the class of protease activated receptor 1 (PAR 1) antagonists. It acts by inhibiting the binding of thrombin to PAR 1 and thereby prevents platelet aggregation. USFDA approved it in May 2014 as the results of clinical trials showed that the benefit risk ratio was high. It is to be used in a dose of 2.5 mg once daily as triple antiplatelet therapy with aspirin and clopidogrel for reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction or peripheral arterial disease. Increase in the incidence of intracranial hemorrhage is the major side-effect seen.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Year:
2015
Type:
Article
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