Zincovit syrup ameliorates oxidative stress induced by carbon tetrachloride in rats.
Article
in English
| IMSEAR
| ID: sea-165102
ABSTRACT
Background:
Zincovit (ZVT) syrup is a combined formulation of vitamins, minerals and lysine. The present study was aimed to investigate the in vivo antioxidant potential of ZVT syrup in carbon tetrachloride (CCl4) intoxicated Wistar rats.Methods:
A total of 36 Wistar rats were divided into six groups of six rats each. Antioxidant potential of ZVT syrup at the dose of 15 mg/kg/day, 30 mg/kg/day and 60 mg/kg/day was evaluated in CCl4 intoxicated rats. The extent of CCl4 induced oxidative stress was studied by estimating malondialdehyde (MDA), glutathione-Stransferase (GST) and catalase (CAT).Results:
Oral treatment with ZVT syrup, especially at the dose of 30 mg/kg/day and 60 mg/kg/day reversed CCl4 - induced alterations in MDA (p<0.05), GST (p<0.01) and CAT (p<0.01) compared to CCl4 intoxicated control (untreated) animals.Conclusion:
The present findings revealed that ZVT syrup may be useful in oxidative stress associated tissue damage as a nutritional food supplement.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Year:
2015
Type:
Article
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