Correlation Of Bone Turnover Markers With Age, BMI And Serum Oestradiol In Pre And Postmenopausal Urban Women.

ABSTRACT

Abstracts Background: Rapid bone loss occurs in women after menopause due to hormonal factors that lead to an increased susceptibility to fractures. This study was done to find out the correlation of osteocalcin and telopeptide-C with age, body mass index (BMI) and oestradiol in premenopausal and postmenopausal women. Methodology: Study was conducted on 350 women aged 30–65 years who were classified into premenopausal and postmenopausal groups. Serum samples were analysed for oestradiol, osteocalcin and telopeptide-C. Pearsons correlation was used for statistical confirmations. Results: Osteocalcin was found to be correlated with age (r= +0.56, p<0.001), BMI (r= -0.39, p<0.001), oestradiol (r= -0.21, p<0.01) and telopeptide-C (r= +0.18, p<0.05) in postmenopausal women but no correlation was found in premenopausal women. Telopeptide-C was found to be correlated with age (r= +0.39,p<0.001), BMI (r= -0.29,p<0.001) and oestradiol (r= -0.48,p<0.001) in postmenopausal women; in premenopausal women it was found to be correlated with BMI (r= -0.30,p<0.001) and oestradiol (r= -0.29,p<0.001). Conclusion: Inverse correlation of Telopeptide-C with BMI and serum oestradiol in premenopausal and postmenopausal women suggests that their increased bone turnover was linked to low BMI and oestrogen deficiency.