Examination of CNS Activity of Rhizomes of Alpinia Oxyphylla.

ABSTRACT

The study is based on the examination of the CNS activity observed from the methanolic extract of the rhizomes of Alpinia oxyphylla. Tail immersion method in mice has been used for the evaluation of the central pharmacological actions. Similarly acetic-acid induced writhing-test was used for the evaluation of the peripheral pharmacological properties. A significant rise in pain threshold is seen in a dose dependent manner with the methanolic extract of A. oxyphylla at doses of 100, 200 and 400 mg/kg body weight with the tail immersion methods. The methanolic extract at 400 mg/kg dose possessed 73.12% writhing inhibition, (p <0.001) in acetic-acid induced writhing-test that could be compared to the standard, Diclofenac-Na (25 mg/kg) with 75.78% inhibition. Open-field and hole-cross tests have been conducted in mice for further investigation of the extract in support of its neuro-pharmacological actions, where dosedependent suppression of exploratory and motor activities were observed in the tested models. Hence, the above results evidence the presence of CNS depressant and analgesic properties of the plant, A. oxyphylla.