Study of Serum Total Calcium, Ionized Calcium and Total Protein Concentrations in Postmenopausal Women.

ABSTRACT

Menopause and ageing is associated with accelerated loss of cortical bone. Osteoporotic fractures are common cause of morbidity and mortality in adult Indian women due to ageing. This study was conducted to evaluate the levels of serum calcium, ionized calcium and total protein levels in postmenopausal women and to assess its relation with ageing. Study includes 70 women (40 post menopausal and 30 premenopausal women) serum alkaline phosphatase, serum calcium, ionized calcium and total proteins, serum albumin were estimated in both cases and controls. There is decrease in serum calcium in postmenopausal; women when compared to premenopausal women. There was no significant change in ionized calcium in both cases and controls. ALP is highly significant P<0.001. In postmenopausal women suggesting there is high alkaline phosphotase activity in postmenopausal women as a result of the inhibitory effects of estrogen on bone turnover rate which is dependent on age and body mass index. Decrease in serum albumin was seen in postmenopausal women which is the reason for decrease in serum calcium level which is inturn related to ageing effect.