Hepatoprotective Effect of Mussaenda Erythrophylla and Aegle Marmelos in Ethanol Induced Rat Hepatotoxicity Model.

ABSTRACT

Aim: To assess the protective effect of ethanolic leaf extract of Mussaenda erythrophylla and Aegle marmelos in ethanol induced hepatotoxicity. Methods: The ethanolic extract M. erythrophylla (ME) and A. marmelos (AM) studied for its hepatoprotective effect on alcohol induced acute liver damage on Wistar albino rats. The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), total bilirubin (TBL), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione (GSH), and total antioxidant (TAC) levels. Results: Alcohol treated group had enhanced levels of SGPT, SGOT, total bilirubin (p <0.05) and decreased levels of GSH, SOD and GPx (p <0.05) when compared with control group. Treatment with silymarin and 200mg/kg of M. erythrophylla and A. marmelos leaf extract had significantly (p <0.01) brought down the elevated levels of SGPT, SGOT, and total bilirubin and an increase in the levels of GSH, SOD, GPx (p <0.001) and total antioxidant. (p <0.0001) Conclusion: The results showed that ethanolic extract of M. erythrophylla and A. marmelos leaves extracts possesses significant hepatoprotective activity.