Outcome of Very Low Birth Weight Infants with Abnormal Antenatal Doppler Flow Patterns: A Prospective Cohort Study.
Indian Pediatr
;
2013 September; 50(9): 847- 852
Article
in English
| IMSEAR
| ID: sea-169971
ABSTRACT
Background:
Fetal growth restriction and abnormal Doppler flow studies are commonly associated. Neonatal outcomes are not well known particularly in developing countries, where the burden of the disease is the highest.Objective:
To determine outcomes of preterm infants with history of absent/reversed end-diastolic umbilical artery Doppler flow (AREDF) vs. infants with forward end-diastolic flow (FEDF).Design:
Cohort study.Setting:
Tertiary care perinatal center in India.Participants:
103 AREDF very low birth weight (<1500 gm) (VLBW) infants and 117 FEDF VLBW infants were prospectively enrolled.Results:
At 40 weeks adjusted post-menstrual age, AREDF vs. FEDF group had a higher risk for death in the NICU (12% vs. 1%), respiratory distress syndrome (33% vs. 19%), and cystic periventricular leukomalacia (12% vs. 1%). At 12-18 months corrected age, AREDF vs. FEDF group had a trend towards increased risk for cerebral palsy (7% vs. 1%, P=0.06). After logistic regression analysis, adjusting for confounders, AREDF was independently associated only with mortality in the NICU.Conclusion:
AREDF is an independent predictor of adverse outcomes in preterm infants in a developing country setting.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Etiology study
/
Observational study
/
Prognostic study
Language:
English
Journal:
Indian Pediatr
Year:
2013
Type:
Article
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