Intellectual Disability in Indian Children: Experience with a Stratified Approach for Etiological Diagnosis.
Indian Pediatr
;
2013 December; 50(12): 1125-1130
Article
in English
| IMSEAR
| ID: sea-170093
ABSTRACT
Objective:
To study the clinico-etiological profile of children with intellectual disability using an algorithmic approach.Design:
Cross-sectional study.Setting:
Tertiary care centre in Northern India.Participants:
Consecutive children aged 3 months to 12 years, presenting with intellectual disability, confirmed by Developmental Assessment Scale for Indian Infants, Binet Kulshreshtha Test and Vineland Social Maturity Scale.Method:
All children were assessed on an internally validated structured proforma. A targeted approach included thyroid function tests, Brainstem evoked response audiometry, electroencephalogram, neuroimaging and metabolic screen done as a pre-decided schema. Genetic tests included karyotyping, molecular studies for Fragile X, Multiplex Ligation Dependent Probe Amplification and Array Comparative Genomic Hybridisation.Results:
Data of 101 children (median age 22 months) was analyzed. The etiological yield was 82.1% with genetic causes being the most common (61.4%) followed by perinatal acquired (20.4%), CNS malformations (12%), external prenatal (3.6%), and postnatal acquired (2.4%). Mild delay was seen in 11.7%, moderate in 21.7%, severe in 30.6% and profound in 35.6%.Conclusion:
It is possible to ascertain the diagnosis in most of the cases of intellectual disability using a judicious and sequential battery of tests.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
Language:
English
Journal:
Indian Pediatr
Year:
2013
Type:
Article
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