Plasma Exchanges and Immunosuppression for Anti-complement Factor H Associated Hemolytic Uremic Syndrome.

ABSTRACT

Background: Atypical hemolytic uremic syndrome associated with autoantibodies to complement factor H is an important cause of acute kidney injury; most patients require dialysis and are at risk of progressive renal failure. Case Characteristics 7 patients with gastrointestinal symptoms, acute kidney injury, thrombotic microangiopathy and elevated levels of anti-complement factor H antibodies. Intervention Prompt initiation of plasma exchanges and immunosuppression. Outcome: Remission of hematological and kidney functions. Message Prompt and specific management of antibody associated hemolytic uremic syndrome is associated with favorable outcome.