Parotid Gland Enlargement as a Presenting Manifestation of Acute Lymphoblastic Leukemia

ABSTRACT

A young female presented with symmetric polyarthritis, generalized lymphadenopathy, hepatosplenomegaly and bilateral parotid gland enlargement without sicca symptoms. A second case of 15 months old child presented with short duration pyrexia with generalized lymphadenopathy, hepatosplenomegaly and bilateral parotid gland enlargement. Both the patients had out of proportion anemia on examination. Investigations confirmed CD 10+ B-cell acute lymphoblastic leukemia (ALL) in both the cases. Fine needle aspiration cytology of parotid glands in both the cases showed infiltration by lymphoblasts.We propose that ALL should be included in the differential diagnosis of bilateral parotid gland enlargement especially if associated with lymphadenopathy and hepato-splenomegaly.