Short-term Ibuprofen Treatment and Pulmonary Function in Children with Asthma.
Indian Pediatr
;
2015 Aug; 52(8): 691-693
Article
in English
| IMSEAR
| ID: sea-171849
ABSTRACT
Objective:
To investigate the association between ibuprofen use and pulmonary function in children with Asthma.Methods:
Ninety 9- to 10-year-old children were classified into 3 groups Study group, mild to moderate stable asthmatic children with self-reported aspirin allergy and no history of anaphylaxis; Allergy control group atopic children (allergic rhinitis/atopic dermatitis); Healthy control group non-atopic healthy children. None of the participants in the atopic and healthy control groups had a history of aspirin allergy. All received ibuprofen 4 times a day for 3 consecutive days. Forced expiratory volume in the first second (FeV1) and fractional exhaled nitric oxide (FeNO) measurements were performed before and after ingestion of ibuprofen daily for 3 days.Results:
In the study group, a decrease in FeV1 and increase in FeNO levels were observed after taking ibuprofen for 2 days. The atopic control group showed only an increase in FeNO but not FEV1. In the healthy control group, both FeV1 and FeNO were unchanged from baseline.Conclusions:
The results showed that cross-reactive non-steroidal anti-inflammatory drug hypersensitivity may exist between ibuprofen and aspirin. This raises the possibility that asthma exacerbation could be mediated by ibuprofen ingestion.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Journal:
Indian Pediatr
Year:
2015
Type:
Article
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