Umbilical Cord Milking and Hematological Parameters in Moderate to Late Preterm Neonates: A Randomized Controlled Trial.

ABSTRACT

Objective: To investigate the effect of umbilical cord milking on hematological parameters at 6 weeks of age in late preterm neonates. Design: Randomized controlled trial. Setting: A tertiary care center of Northern India during 2013-14. Participants: 200 moderate to late preterm neonates randomly allocated to early cord clamping or umbilical cord milking group (100 in each). Intervention In milking group, 25 cm length of cord was milked towards the baby thrice after separating (within 30 s) it from placenta. Main outcome measures: Hemoglobin and serum ferritin at 6 weeks of age. Results: Mean (SD) serum ferritin [428.9 (217.6) vs. 237.5 (118.6) ng/mL; P< 0.01] and hemoglobin [12.1 (1.5) vs. 10.4 (1.2) gm/dL; P<0.01] at 6 weeks were significantly higher in umbilical cord milking group. In early neonatal period, hemodynamic and hematological parameters were not significantly different. Higher incidence of jaundice with higher phototherapy rates (33% vs. 9%; P<0.01) were noted in umbilical cord milking group. Conclusion: In preterm neonates, umbilical cord milking at birth enhances iron stores at 6 weeks of age. Higher phototherapy rates with this intervention are a matter of concern.