Insulin Secretory Status in Obese Female.
Article
in English
| IMSEAR
| ID: sea-171994
ABSTRACT
Background:
In obesity insulin hypersecretion is a key feature indicating the abnormal pancreatic beta cell function which is the fundamental defect in the development of NIDDM, hypertension and cardiovascular diseases.Objective:
To assess the secretory status of insulin in adult obese female.Methods:
The present study was a cross sectional analytical study and conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2012 to June 2013. 50 obese female subjects of 20-40 years were included from Out-patient Department (Obesity clinic) of BIRDEM Hospital, Dhaka and by personal contact from different areas of Dhaka city. 50 age matched, healthy non-obese female subjects selected as controls . Fasting serum insulin level was measured by ELISA and fasting glucose level was measured by Glucose oxidase method. The insulin secretory status was calculated by HOMA-%B using HOMA software. For statistical analysis unpaired Student’s ‘t’ test and Pearson’s correlation coefficient (r) test were performed as applicable .Result:
Mean fasting serum insulin and HOMA%B (P<0.001) were higher in the obese than that non obese. Fasting serum insulin level and HOMA%B showed significantly positive correlation with WHR.Conclusion:
This study concludes that obese individual develops a state of insulin hypersecretion and hyperinsulinemia.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Year:
2014
Type:
Article
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