Hyperinsulinemia and Other Risk Factors in Endometrial Carcinoma.

ABSTRACT

Thirty Patients of Histologically confirmed endometrial carcinoma admitted and treated over a period of three years in the department of obstetrics and Gynecology Govt Medical College Jammu, were studied to evaluate the risk factors in endometrial Carcinoma. The major risk factors in this study were hyperinsulinemia, hypertension, obesity and increasing age. Hyperinsulinemia has a potential role in growth and development of endometrial carcinoma, as insulin, in postmenopausal women with endometrial carcinoma, leads to increased stromal secretion of androstenedione which gets aromatized to form unbound oestradiol, having proliferative action on endometrium. The other risk factors noted in the study were early menarche, heavy menstrual flow, late menopause and diabetes. Since most of the risk factors are associated with hyperinsulinemia and insulin resistance, hyperinsulinemia can act as a good clinical marker in patients of endometrial carcinoma.