Correlation between Acetaminophen Consumption and CSF Glucose Level in Febrile Convulsion.

ABSTRACT

Hyperglycemia and hyperglycorrhagia common occur in children with febrile seizures. Rapid release of cortisol and adrenaline after seizures as a stress reaction induce elevated glucose concentration in Cerebral Spinal Fluid (CSF). The purpose of this study was to assess the correlation between acetaminophen consumption and CSF glucose level in children with febrile convulsion.This cross- sectional study was performed over 3-18 months old children who were admitted at pediatric section of teaching hospital during 7 years. Comparisons between the mean CSF glucose concentrations in the children who taken and no taken acetaminophen during 6 hours before convulsion was performed using Student's t-test and Mann- Whitney test.The glucose level in the CSF of children who no taken acetaminophen (82±8 mg/dl) was significantly higher than children taken acetaminophen (53±4 mg/dl). (P=0.0001).The use of acetaminophen before convulsion decrease CSF glucose concentration in febrile convulsive children