Effect of preoperative statin therapy on early postoperative memory impairment after off‑pump coronary artery bypass surgery.
Ann Card Anaesth
;
2016 Jan; 19(1): 38-44
Article
in English
| IMSEAR
| ID: sea-172270
ABSTRACT
Context Frequent incidence of early postoperative memory impairment (POMI) after cardiac surgery remains a concern because of associated morbidity, impaired quality of life, and increased health care cost. Aim:
To assess the effect of preoperative statin therapy on POMI in patients undergoing off‑pump coronary artery bypass (OPCAB) surgery. Setting andDesign:
Prospective observational study in a tertiary level hospital.Methods:
Sixty patients aged 45–65 years undergoing OPCAB surgery were allocated into two groups of 30 each. Group A patients were receiving statin and Group B patients were not receiving statins. All patients underwent memory function assessment preoperatively after admission to hospital and on the 6th postoperative day using postgraduate institute memory scale. StatisticalAnalysis:
Appropriate tests were applied with SPSS 20 to compare both groups. The value P < 0.05 was considered statistically significant. Multiple regression analysis was performed with confounding factors to determine the effect on memory impairment.Results:
Patients in Group A showed significant postoperative deterioration in 6 of the 10 functions and in Group B showed deterioration in 9 of 10 functions tested compared to preoperative scores. Intergroup comparison detected less POMI in Group A compared to Group B and was statistically significant in 8 memory functions. Multiple regression analysis detected statin as an independent factor in preventing memory impairment.Conclusions:
Preoperative statin therapy attenuates the early POMI in patients undergoing OPCAB. Future long‑term studies will define the efficacy of statin on POMI.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Observational study
Language:
English
Journal:
Ann Card Anaesth
Year:
2016
Type:
Article
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