Effect of Pre-treatment with Moringa oleifera (Drumstick) Leaves on Diabetogenesis Produced by Alloxan in Rats.
Article
in English
| IMSEAR
| ID: sea-172646
ABSTRACT
Background:
Medicinal plants constitute an important source of potential therapeutic agents for diabetes.Objective:
In the study, we aimed to investigate the pre-treatment effect or preventive effects of Moringa oleifera (MO) leaves on blood sugar of rats. Materials andmethod:
This experimental study was carried out in the department of Pharmacology and Therapeutics of Sir Salimullah Medical College in collaboration with Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka. A total 24 long Evans rats were included in this study and divided in to four groups. Hyperglycemia was induced on rats using alloxan (100 mg/kg body weight, intraperitioneally). Blood sample was collected from tail vein by tail tipping method. Pre-treatment effect or preventive role of Moringa oleifera (drumstick) leaf powder on diabetogenesis produced by Alloxan in rats was tested by giving 50 mg/rat/day Moringa oleifera leaf powder for 14 days orally as pre-treatment along with standard rat feed. Then alloxan was administered intraperitoneally on 15th day of the experiment and 50mg/rat/day Moringa oleifera leaf powder was given for 7 days as post-treatment.Results:
No significant effect of MO on blood glucose level was observed on normal rats and non significant hypoglycaemic effect was found in rats that were pretreated with MO.Conclusion:
The present study suggests that Moringa oleifera leaf powder did not produce any significant protective effect in diabetogenesis produced by alloxan though it has hypoglycaemic effect.
Full text:
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Index:
IMSEAR (South-East Asia)
Language:
English
Year:
2015
Type:
Article
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