Anti-granuloma activity of Coriandrum sativum in experimental models.
J Ayurveda Integr Med
;
2013 Jan-Mar; 4(1): 13-18
Article
in English
| IMSEAR
| ID: sea-173237
ABSTRACT
Background:
Coriandrum sativum has been used in the traditional systems of medicine for management of arthritis and other infl ammatory disorders.Objectives:
In this study, we have evaluated the anti-infl ammatory and anti-granuloma activities of Coriandrum sativum hydroalcoholic extract (CSHE) in experimental models. Materials andMethods:
The anti-infl ammatory activity of CSHE was evaluated using carrageenan-induced paw edema model and the anti-granuloma activity of CSHE was evaluated using the subcutaneous cotton pellet implantation-induced granuloma formation and stimulation of peritoneal macrophages with complete Freund’s adjuvant. Serum tumor necrosis factor- (TNF-), IL-6, IL-1 levels, and peritoneal macrophage expression of TNF-R1 were evaluated as markers of global infl ammation.Results:
CSHE at the highest dose tested (32 mg/kg) produced a signifi cant reduction (P0.05) in paw edema after carrageenan administration. CSHE treatment also reduced dry granuloma weight in all treated animals. Serum IL-6 and IL-1 levels were signifi cantly (P0.05) lower in the CSHE (32 mg/kg)-treated group as compared to control. Although there was an increase in serum TNF- level in the CSHE-treated group as compared to control, TNF-R1 expression on peritoneal macrophages was found to be reduced.Conclusion:
Thus, the result of this study demonstrates the anti-infl ammatory and anti-granuloma activities of CSHE in experimental models, and validates its traditional use for the management of arthritis and other infl ammatory disorders.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Prognostic study
Language:
English
Journal:
J Ayurveda Integr Med
Year:
2013
Type:
Article
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