Effect of Gmelina arborea Roxb in experimentally induced infl ammation and nociception.
J Ayurveda Integr Med
;
2013 July-Sept; 4(3): 152-157
Article
in English
| IMSEAR
| ID: sea-173312
ABSTRACT
Background:
Gmelina arborea Roxb (Verbenaceae), also known as “Gambhari”, is an important medicinal plant in the Ayurveda. There are no meticulous scientifi c reports on effect of the plant on infl ammation and pain.Objective:
To study the anti-infl ammatory and anti-nociceptive properties of aqueous extracts (AE) and methanol extracts (ME) of G. arborea. Materials andMethods:
The AE and ME of stembark of G. arborea was prepared by cold maceration and Soxhlet extraction technique respectively. Anti-infl ammatory activity was determined in Wistar albino rats in a model of acute plantar infl ammation induced by carrageenan. The anti-nociceptive activity was evaluated by using hot plate test and writhing test in Swiss albino mice. Signifi cant differences between the experimental groups were assessed by analysis of variance.Results:
AE and ME at dose of 500 mg/kg showed maximum inhibition in carrageenan induced infl ammation up to 30.15 and 31.21% respectively. In hot plate test, the AE and ME showed the maximum response of 8.8 ± 0.97 (P < 0.01) and 8.2 ± 1.24 (P < 0.01) respectively at dose of 500 mg/kg when compared with control. AE showed maximum inhibition of writhing response (84.3%) as compared to ME (77.9%) in writhing test at a dose of 500 mg/kg.Conclusion:
The fi ndings suggested that G. arborea possess signifi cant anti-infl ammatory and anti-nociceptive activities.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Journal:
J Ayurveda Integr Med
Year:
2013
Type:
Article
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