Analgesic and Anti‑inflammatory action of Opuntia elatior Mill fruits.

ABSTRACT

Background: Opuntia elatio Mill is a xerophytic plant with potentially active nutrients. It is traditionally appreciated for its pharmacological properties; however, the scientific information on this plant is insufficient. Objective: The present study evaluates the antinociceptive and anti‑inflammatory action of prickly pear. Materials and Methods: Writhing and tail‑immersion tests were carried out to evaluate analgesic action, while the carrageenan‑induced paw edema and neutrophil adhesion tests were conducted in Albino wistar rats to assess anti‑inflammatory action. Results: ED50 values of the fruit juice in writhing, tail immersion, and paw edema test were 0.919, 2.77, and 9.282 ml/kg, respectively. The fruits of Opuntia produced analgesic and anti‑inflammatory action in a dose‑dependent manner. Conclusion: The results establish the folklore use of prickly pear may be due to the presence of betacyanin and/or other phenolic compounds.