Spasmolytic effect of traditional herbal formulation on guinea pig ileum.
J Ayurveda Integr Med
;
2015 July-Sept; 6(3): 194-197
Article
in English
| IMSEAR
| ID: sea-173702
ABSTRACT
Background:
The herbal formulation consisting of Andrographis paniculata Nees., Cassia fistula L., Foeniculum vulgare Mill. and Cuminum cyminum L. is widely used by the local traditional practitioners in rural Northern Karnataka for spasmodic abdominal pain.Objective:
The present study was undertaken to evaluate safety and spasmolytic effect of poly‑herbal formulation. Materials andMethods:
Acute toxicity studies were carried out in Swiss mice, as per the Organization for Economic Co‑operation and Development (OECD) guidelines. The spasmolytic activity of the formulation was studied in isolated guinea pig ileum model using histamine and acetylcholine as agonists. The data were analyzed by one‑way ANOVA, followed by Dunnetts post‑hoc test and P ≤ 0.05 was considered as significant.Results:
The formulation did not show any adverse toxic effects and found to be safe. It also showed significant (P < 0.05) relaxation in different agonist like histamine and acetylcholine‑induced contractions in guinea pig ileum.Conclusions:
Antispasmodic activity of the herbal formulation can be attributed to its atropine‑like activity. The present findings, therefore, support its utility in spasmodic abdominal pain.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Prognostic study
Language:
English
Journal:
J Ayurveda Integr Med
Year:
2015
Type:
Article
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