Effect of Diclofenac Sodium At Low Concentration Level On The Rate Of Orthodontic Tooth Movement In Rat.

ABSTRACT

The purpose was to evaluate the influence of a NSAID, Diclofenac Sodium (DFS) on the tissue reaction related to orthodontic tooth movement (OTM). Methods: 27 adult male wistar rats were divided into 3 Groups of 9 each. Orthodontic closed coil spring was placed between rat incisor and molar to produce a 50 gm of force. The experimental Groups1 and 2 received orthodontic force and either DFS of 0.0025mg/0.05ml or 0.05ml of saline, Group 3 received only orthodontic force and served as a control group. At the end of day 5, 10 and 15 the animals were sacrificed and histological examination was performed. Results: Student’s t test showed a statistically significant difference between the control Groups and experimental Groups. Group 1 showed a statistically significant reduction in osteoclastic cell count at day 5, 10 and15 when compared to Group 2 and Group 3. Conclusion: The results indicate that the Diclofenac Sodium even at low concentration level diminishes the number of osteoclasts probably by inhibiting the secretion of prostaglandins there by reducing the OTM.