Central auditory toxicity of sisomicin in guineapigs.
Article
in En
| IMSEAR
| ID: sea-17476
ABSTRACT
The central auditory toxicity of sisomicin was studied in guineapigs administered sisomicin (135 mg/kg body weight) sc for 10 days. Total lipids, phospholipids and cholesterol were estimated in the pons, inferior colliculus, medial geniculate body and auditory cortex. While the total lipids were increased in a non-preferential manner in all the regions studied, phospholipids and cholesterol levels registered no change. This study suggests the possible central auditory toxicity following sisomicin administration.
Full text:
1
Index:
IMSEAR
Main subject:
Phospholipids
/
Auditory Cortex
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Auditory Pathways
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Male
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Inferior Colliculi
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Pons
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Sisomicin
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Cholesterol
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Drug Evaluation, Preclinical
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Geniculate Bodies
Language:
En
Year:
1991
Type:
Article