Dietary Risk Factors for Sporadic Creutzfeldt- Jakob Disease: A Confirmatory Case-Control Study.
Br J Med Med Res
;
2014 Apr; 4(12): 2388-2417
Article
in English
| IMSEAR
| ID: sea-175181
ABSTRACT
Aims:
This study’s primary purpose was to determine whether earlier findings suggesting an association between sporadic Creutzfeldt-Jakob disease (sCJD), a transmissible spongiform encephalopathy of humans and specific dietary components could be replicated. The a priori hypotheses were that consumption of (i) foods likely to contain organ tissue and (ii) raw/rare meat are associated with increased sCJD risk. StudyDesign:
Population-based case-control study. Place and Duration of Study Department of Neurology, School of Medicine, Loma Linda University, Loma Linda, CA, USA; 4 years.Methodology:
An 11-state case-control study of pathologically confirmed, definite sCJD cases, matched controls, and a sample of control-surrogates was conducted. Ninety-six percent (106/110) of the case data was obtained in 1991-1993, prior to variant CJD publicity.Results:
Using control self-responses, consumption of hot dogs, sausage, pepperoni, kielbasa, "other" canned meat, poultry liver, any stomach/intestine, beef stomach/intestine, any organ tissue, and beef organ tissue was individually associated with increased sCJD risk; odds ratios (OR) ranged from 2.4 to 7.2 (0.003 <p<0.025). Rare/raw meat consumption was associated with sCJD (OR=2.0; p<0.05). Greater consumption of hot dogs, bologna, salami, sausage, pepperoni and kielbasa was associated with significantly higher risk. The OR for gizzard consumption was 7.6, p<0.04. Bologna, salami, any liver, beef liver and pork stomach/intestine were marginally associated with sCJD ORs ranged from 1.7 to 3.7; 0.05 <p< 0.10. Brain consumption was not associated with an elevated risk. Analyses using control-surrogate data indicate that use of the control self-responses did not bias the results away from the null hypothesis.Conclusions:
The a priori hypotheses were supported. Consumption of various meat products may be one method of transmission of the infectious agent for sCJD.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Etiology study
/
Observational study
/
Risk factors
Language:
English
Journal:
Br J Med Med Res
Year:
2014
Type:
Article
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