Vitamin E Supplementation Improves Oxidant-antioxidant Balance in Chronic Renal Failure Patients Treated by Hemodialysis.
Br J Med Med Res
;
2014 Aug; 4(24): 4169-4177
Article
in English
| IMSEAR
| ID: sea-175390
ABSTRACT
Aims:
The purpose of this study was to evaluate the effect of vitamin E supplementation on oxidant-antioxidant balance in chronic renal failure patients treated by hemodialysis. StudyDesign:
The study utilized a randomized experimental design. The experimental intervention consisted of vitamin E supplementation Place and Duration of Study 40 patients on hemodialysis (M/W=22/18; 36±12 years) received nutritional councils based on the NKF K/DOQI (National Kidney Foundation- Kidney Disease Outcomes Quality Initiative) guidelines. Patients were randomized into 2 groupsone was used as control and the second group was treated by vitamin E supplementation (100mg/day=146IU/d) during 30 days.Methodology:
Pro-oxidant status was assessed by thiobarbituric acid reactive substances, hydroperoxides and carbonyls analysis. Antioxidant defence was performed by the analysis of Superoxide dismutase, Catalase, Glutathione reductase activities and Vitamin E amounts.Results:
At 30 days of supplementation, in treated patients compared to controls, levels of triacylglycerols and total cholesterol were unchanged. Hydroperoxides concentrations were decreased (p<0.001) while thiobarbituric acid reactive substances concentrations were unchanged. Carbonyls levels were decreased (p<0.001). High concentrations of vitamin E were noted in treated group (p<0.01). Similar superoxide dismutase activity was noted. However, an increase in vitamin E concentrations, catalase and glutathione reductase activities were observed in treated group (p<0.01).Conclusion:
In conclusion, in hemodialysis patients, vitamin E supplementation was without effect on lipid profile. However, vitamin E exerts a protective effect on cardiovascular diseases by decreasing radical attack of biological molecules and increasing antioxidant defense.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Controlled clinical trial
Language:
English
Journal:
Br J Med Med Res
Year:
2014
Type:
Article
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