Study of Different Adjuvant Treatment Regimens as a Complement to Surgery in Patients with Carcinoma Anorectum.

ABSTRACT

Background: In the present study we have done a retrospective as well as prospective studies of patients with carcinoma anorectum undergoing abdominoperineal resection with special emphasis on the role of adjuvant treatment regimens as a complement to surgery. Methods: 75 patients operated for APR were studied retrospectively and 25 patients operated for the same were studied prospectively. Results: It was observed that colorectal cancer is the most common malignancy of the gastrointestinal tract. Rectum remains the most common site affected by it. Carcinoma anal canal is about one tenth as common as rectal cancer. Adjuvant treatment after surgery was studied with respect to the indications, the schedules followed and the subsequent complications. Conclusion: It was concluded that adjuvant treatment, in the form of Radiotherapy and Chemotherapy, has a definitive role in, both locally advanced Carcinoma Anorectum and for Dukes' C stage but it has its own complications which need to be addressed. Nigro's chemoradiation regimen has become the first choice for carcinoma anal canal, ahead of APR.