Phaleria macrocarpa Fruits Methanolic Extract Reduces Blood Pressure and Blood Glucose in Spontaneous Hypertensive Rats (SHR).

ABSTRACT

Methanolic extract of Phaleria macrocarpa fruits was evaluated for the anti-hypertensive and anti-hyperglycaemic capacity. For a period of three weeks, 18 male young Spontaneous Hypertensive Rats (SHR) were divided into three experimental groups and received commercial rat pellets as their maintenance diet. At the same duration, SHR in Group 1 received 2 ml/kg/day of distilled water and served as a negative control. Meanwhile, SHR in Group 2 and Group 3 received 0.5 mg/kg/day of Telmisartan (positive control) and 500 mg/kg/day P. macrocarpa fruits methanolic extract, respectively. Bodyweight, arterial blood pressure and blood glucose were measured on a weekly basis. All SHR showed significant increased (p<0.05) in their bodyweight but did not differ significantly (p>0.05) between groups. Blood pressure and blood glucose significantly decreased (p<0.05) in SHR treated with Telmisartan and P. macrocarpa compared to negative control. These results lead us to conclude that P. macrocarpa fruits methanolic extract exhibit anti-hypertensive and anti-hyperglycaemic activities.