Molar Refraction and Polarizability of Antiemetic drug 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2 methoxybenzamide hydrochloride monohydrate in {Aqueous-Sodium or Lithium Chloride} Solutions at 30oC.

ABSTRACT

The 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2 methoxybenzamide hydrochloride monohydrate exhibits antiemetic and parasympathomimetic activity. Density () and refractive index (nD) measurements were carried out as a function of drug concentration (c=0.01-0.11 mol·L-1) in aqueous NaCl/LiCl (c=0.05, 0.10 and 0.15 mol·L-1) solutions at 30oC. Linear relation of concentration dependence of density and refractive index were studied. Molar refractivity (RM) of solution was calculated from density and refractive index data and polarizability () was calculated from molar refractivity data. Stronger polarizability effects have been observed with increase in drug concentration.