Effect Of Sex Hormonal Changes On Serum Lipid Profile In Diabetic And Non-Diabetic Indian Females.

ABSTRACT

Background: Sex hormones and impaired glucose metabolism resulting from Insulin abnormalities are the major important determinants in the development of coronary heart disease (CHD) in females. The present work was envisaged to study the effect of sex hormonal changes on serum lipids in females of different age groups and physiological status i.e. menstruation and menopause. Methodology: The comparisons were made between diabetic females of both the phases (menstruation and menopause) and age matched non-diabetic females. Further comparisons were made between diabetic females of menopause phase and diabetic females of menstruation phase. Results: In the study when comparisons were made between menstruating diabetics and menstruating non-diabetics, the former group showed significant increase in plasma glucose, serum total cholesterol (TC), Triglyceride (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels. Similarly comparisons were made between menopausal diabetics and menopausal non-diabetics, the former group showed significantly higher levels of plasma glucose, serum TC, TG, LDL and VLDL. However it is noticed that HDL levels did not very significantly in both the comparisons. Also in diabetic menopausal females there is a significant increase in serum TG levels as compared to diabetic menstruating females. Conclusions: In present study, in non-diabetic menopausal females there is a significant increase in plasma glucose, serum TC, TG, LDL and VLDL concentration levels as compared to non-diabetic menstruating females. Also in diabetic menstruating and menopausal females, there is a significant increase in plasma glucose, TC, TG and VLDL levels as compared to non-diabetic menstruating and menopausal females.