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Central noradrenergic & dopaminergic modulation of brewer's yeast-induced inflammation & nociception in rats.
Article in English | IMSEAR | ID: sea-17774
ABSTRACT
The possibility of central noradrenergic and dopaminergic modulation of Brewer's yeast-induced peripheral inflammation was investigated in rats. Centrally administered noradrenaline (NA), amphetamine, which liberates NA and dopamine in the central nervous system and L-dopa, the precursor of dopamine significantly suppressed paw oedema. Conversely, the beta-adrenoceptor blocker, propranolol, catecholaminergic neuron degenerator, 6-hydroxydopamine (6-OHDA), dopaminergic antagonist, haloperidol and dopamine synthesis inhibitor, alpha-methyl para tyrosine (AMPT) augmented paw oedema. In addition, 6-OHDA and haloperidol produced significant reduction in pain threshold. The results of this study indicate that central NA and dopamine exert inhibitory effects on Brewer's yeast-induced peripheral inflammation.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pain / Rats / Saccharomyces cerevisiae / Sympathomimetics / Male / Dopamine / Norepinephrine / Rats, Sprague-Dawley / Amphetamine / Inflammation Language: English Year: 1997 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pain / Rats / Saccharomyces cerevisiae / Sympathomimetics / Male / Dopamine / Norepinephrine / Rats, Sprague-Dawley / Amphetamine / Inflammation Language: English Year: 1997 Type: Article