Central noradrenergic & dopaminergic modulation of brewer's yeast-induced inflammation & nociception in rats.
Article
in English
| IMSEAR
| ID: sea-17774
ABSTRACT
The possibility of central noradrenergic and dopaminergic modulation of Brewer's yeast-induced peripheral inflammation was investigated in rats. Centrally administered noradrenaline (NA), amphetamine, which liberates NA and dopamine in the central nervous system and L-dopa, the precursor of dopamine significantly suppressed paw oedema. Conversely, the beta-adrenoceptor blocker, propranolol, catecholaminergic neuron degenerator, 6-hydroxydopamine (6-OHDA), dopaminergic antagonist, haloperidol and dopamine synthesis inhibitor, alpha-methyl para tyrosine (AMPT) augmented paw oedema. In addition, 6-OHDA and haloperidol produced significant reduction in pain threshold. The results of this study indicate that central NA and dopamine exert inhibitory effects on Brewer's yeast-induced peripheral inflammation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain
/
Rats
/
Saccharomyces cerevisiae
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Sympathomimetics
/
Male
/
Dopamine
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Norepinephrine
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Rats, Sprague-Dawley
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Amphetamine
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Inflammation
Language:
English
Year:
1997
Type:
Article
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