Effect of pinacidil on the contractile response of cyclophosphamide-treated rat vas deferens.
Article
in English
| IMSEAR
| ID: sea-17783
ABSTRACT
Effect of pinacidil, a K+ channel opener, was studied on contractility of cyclophosphamide-treated rat vas deferens. The mean IC50 value of pinacidil against 1 mmol barium chloride induced rhythmic contractions and 40 mmol potassium chloride induced tonic contractions was significantly (P < 0.01 and P < 0.001, respectively) increased in the cyclophosphamide treated group as compared to the control. The mean EC50 value of norepinephrine (NE) in the presence of pinacidil (10(-6) mol) was significantly (P < 0.001) increased in the cyclophosphamide treated group. These findings indicate that the responsiveness of rat vas deferens smooth muscle to pinacidil is reduced following cyclophosphamide treatment.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Vas Deferens
/
Male
/
Potassium Channels
/
Norepinephrine
/
Calcium
/
Antineoplastic Agents, Alkylating
/
Pinacidil
/
Cyclophosphamide
/
Animals
Language:
English
Year:
1999
Type:
Article
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