Effects of isotretinoin on the thyroid gland and thyroid function tests in acne patients: A preliminary study.
Indian J Dermatol Venereol Leprol
;
2016 Sept-Oct; 82(5): 587-588
Article
in English
| IMSEAR
| ID: sea-178489
ABSTRACT
Background:
Isotretinoin is widely used in the treatment of acne.Aims:
We investigated the effects of isotretinoin on thyroid function tests and thyroid volume in acne patients.Methods:
In this prospective study, a total of 104 acne patients were included. Sixty-six patients were treated with isotretinoin for at least 4 months. Thirty eight patients were included in the control group. The levels of thyroid stimulating hormone, free triiodothyronine, free thyroxine, antithyroglobulin and antithyroid peroxidase antibodies were measured and a thyroid ultrasound was performed in all the subjects before treatment and 4 months after treatment. A “p” value of < 0.05 was considered signifi cant.Results:
In the isotretinoin-treated group, thyroid stimulating hormone levels increased significantly during isotretinoin treatment (P = 0.018). Free triiodothyronine, free thyroxine, anti-thyroid peroxidase levels and thyroid volume decreased signifi cantly during treatment (P = 0.016, P = 0.012, P = 0.006, P = 0.020 respectively).Limitations:
The major limitation of this study is the lack of follow-up data after the cessation of isotretinoin therapy in acne patients.Conclusion:
Patients treated with isotretinoin should be monitored with thyroid function tests.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Observational study
Language:
English
Journal:
Indian J Dermatol Venereol Leprol
Year:
2016
Type:
Article
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