Effect of lanosterol on human cataract nucleus.

ABSTRACT

Aim: To study the effect of lanosterol on age‑related cataractous human lens nuclei. Materials and Methods: Forty age‑related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol solution or in control solution and stored at room temperature for 6 days. Pre‑ and post‑immersion photographs were graded by two masked observers and collated for the regression or progression of lens opacity. Results: Both lanosterol and control groups showed progression or no change in the lens opacity at the end of 6 days. Conclusion: Lanosterol 25 mM solution did not reverse opacification of human age‑related cataractous nuclei.