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The efficacy of intravitreal interferon alpha‑2b for the treatment of experimental endotoxin‑induced uveitis
Indian J Ophthalmol ; 2016 May; 64(5): 376-381
Article in English | IMSEAR | ID: sea-179278
ABSTRACT

Purpose:

To study the efficacy of intravitreal interferon alpha‑2b for endotoxin‑induced uveitis. Materials and

Methods:

A total of 36 rabbits were randomly allocated to one of the three groups (1) received interferon plus balanced‑salt solution; (2) received lipopolysaccharide (LPS) plus interferon; and (3) received LPS plus balanced‑salt solution. Intraocular inflammation was evaluated by slit‑lamp biomicroscopy (standardization of uveitis nomenclature grading), binocular indirect ophthalmoscopy (BIO) score, and histopathology.

Results:

Group 2 showed significantly lower mean (±standard deviation) anterior chamber reaction than Group 3 (3.1 ± 0.9 vs. 3.8 ± 0.4) on day 1 postinjection, lower vitreous cells on days 1 through 7 (day 1 3.1 ± 0.9 vs. 3.8 ± 0.4; day 3 2.1 ± 1.6 vs. 3.8 ± 0.4; day 7 1.9 ± 1.3 vs. 3.6 ± 0.7), and lower BIO score on days 1–7 (day 1 3.3 ± 1.2 vs. 4.4 ± 0.7; day 3 3.0 ± 1.4 vs. 4.3 ± 0.9; day 7 2.4 ± 1.4 vs. 3.7 ± 1.2). The protein content of anterior and vitreous aspirates was lower in Group 2 than 3 (1618.5 ± 411.4 vs. 2567.3 ± 330.8 and 2157.0 ± 283.3 vs. 3204.6 ± 259.5, respectively).

Conclusion:

Intravitreal interferon alpha‑2b was effective in controlling endotoxin‑induced uveitis.

Full text: Available Index: IMSEAR (South-East Asia) Language: English Journal: Indian J Ophthalmol Year: 2016 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Language: English Journal: Indian J Ophthalmol Year: 2016 Type: Article