Slow thaw siphon technique for cryoprecipitate production.

ABSTRACT

The efficacy of the slow thaw siphon technique for making cryoprecipitate was evaluated. A hundred consecutive bags of cryoprecipitate were subjected to analysis. The average Factor VIIIC level in donors plasma was 1.02 IU/ml with slightly lower levels of Factor VIIIC in O group persons and in the older age group. The average Factor VIIIC content per bag of cryoprecipitate was 132 units with the average Factor VIIIC yield of 57.8 per cent. Recovery of the cryoprecipitates made by this method was tested in vivo in ten haemophiliacs with less than 1 per cent activity. An average increment of 1.91 per cent in Factor VIIIC levels was obtained by infusion of 1 IU/kg body weight.