Association of Circulating Orexin-A Level With Metabolic Risk Factors in North Indian Pre Menopausal Women.
Indian J Physiol Pharmacol
;
2015 Oct-Dec; 59(4): 422-427
Article
in English
| IMSEAR
| ID: sea-179500
ABSTRACT
The present study was designed to investigate the association between circulating Orexin-A level with metabolic risk factors in North Indian adult women. 342 women were enrolled for the case-control study, 172 women were with metabolic syndrome (mets) and 170 healthy control women were without metabolic syndrome, (womets) according to (NCEP ATP III criteria). Circulating Orexin-A level was determined by enzyme-linked immunosorbent assay. Observations indicated low levels of orexin-A (26.06±6.09 ng/ml) in women with mets and other metabolic risk factors compared to women without metabolic syndrome (36.50±10.42 ng/ml). Further, in women with metabolic syndrome, circulating Orexin A was significantly associated with waist circumference, triglyceride (negative correlation) and hyperdensity lipoprotein (positive correlation). Our study shows that circulating Orexin A was found to be significantly associated with hyperlipidemia, obesity and obesity-related disorders in North Indian premenopausal women
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Etiology study
/
Observational study
/
Risk factors
Language:
English
Journal:
Indian J Physiol Pharmacol
Year:
2015
Type:
Article
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