Characterization of G6PD Rohini--a new class III Indian variant.
Article
in English
| IMSEAR
| ID: sea-17960
ABSTRACT
A new Indian G6PD variant was detected in a 15 yr old Maratha male during a population screening programme in high school children in Bombay (India). The propositus and two family members having the same variant were apparently healthy. This enzyme variant has a mild erythrocyte G6PD deficiency and a slow electrophoretic mobility. It is characterized by a high Michaelis-Menton constant for G6P, a bimodal curve for pH optima and a slight decrease in the thermostability. The rate of utilization of substrate analogue is similar to that of normal. These observations suggest identification of a new class III variant, designated as G6PD Rohini.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pedigree
/
Genetic Variation
/
Humans
/
Male
/
Child
/
Mass Screening
/
Adolescent
/
Adult
/
Electrophoresis, Starch Gel
/
Erythrocytes
Type of study:
Screening study
Country/Region as subject:
Asia
Language:
English
Year:
1992
Type:
Article
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