Evaluation of Aqueous Leaf Extract of Cissampelos mucronata on Testicular Function Indices in Wistar Rats.
Article
in English
| IMSEAR
| ID: sea-179753
ABSTRACT
Aim:
This study aimed at investigating the effect of aqueous leaf extract of Cissampelos mucronata on testicular function indices in male wistar rats (Rattus novergicus).Methodology:
A total of 20 rats, grouped into four, with a group consisting of five rats were used for the study. The groups were a control administered 1.0 mL of distilled water and three other groups that were respectively administered - 1.0 mL of 300, 600 and 1200 mg/kg body weight of the plant extract. The different groups were administered plant extract orally for 14 days, using metal oropharyngeal cannula.Results:
The results revealed a significant increase (P <0.05) in body weight, testes-body weight ratio, cholesterol and glycogen concentrations at all the doses except at 1200 mg/kg body weight of the animals where decreased glycogen level was observed. There was also significant decrease (P <0.05) in the concentrations of acid phosphatase, alkaline phosphatase and total testicular protein especially in rats administered with 1200 mg/kg body weight of extract while there was no significant change in the activities of gamma glutamyl transferase. Serum testosterone concentration was observed to decrease significantly (P <0.05) only in the rats administered with 300 mg/kg body weight of extract.Conclusion:
The results indicate anti-androgenic and anti-steroidogenic activities of Cissampelos mucronata aqueous leaf extract on males.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Prognostic study
Language:
English
Year:
2015
Type:
Article
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