Age Related Changes in Cerebrovascular Reactivity and Its Relationship to Global Brain Structure.
Br J Med Med Res
;
2015; 7(10): 809-820
Article
in English
| IMSEAR
| ID: sea-180428
ABSTRACT
Introduction:
There is growing evidence to suggest that vascular and CSF haemodynamic effects are related to structural changes in the ageing brain. We investigated these effects in a sample of healthy participants by measuring changes in cerebrovascular reactivity induced by hypercapnia and comparing these to global and ROI based cerebral volume measures.Methods:
Forty five participants aged 21 to 58 years (23 female) were recruited. Cerebrovascular reactivity was determined from hypercapnia induced BOLD signal change during two 3-minute intervals of breathing 6% CO2, interleaved with three 2-minute intervals of breathing room air. Parametric maps of reactivity were calculated as the ratio of % BOLD signal change to end-tidal CO2 (mmHg). High resolution 3D T1-weighted images were segmented and lateral ventricle volume and white matter hypointensity volume determined.Results:
Significant negative correlations between both grey matter (p = .042) and white matter (p = .021) reactivity and age were found and significant negative correlations between grey matter (p = .013) and white matter (p = .004) reactivity and lateral ventricle volume were also found while correcting for age and total intracranial volume. A significant negative correlation between white matter reactivity and white matter hypointensity volume was found (p = .049) after correcting for age.Conclusion:
These results support the hypothesis that cerebrovascular haemodynamics influence structural brain changes that occur during normal ageing that are independent of the age of the individual.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Journal:
Br J Med Med Res
Year:
2015
Type:
Article
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