Goal-directed resuscitation in sepsis: The game continues but the goalposts have been removed.

ABSTRACT

The ARISE Investigators and the ANZICS Clinical Trials Group. Writing Committee––Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, Higgins AM, Holdgate A, Howe BD, Webb SA, Williams P. (The Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine; and the School of Public Health, Monash University, Melbourne, Victoria; University of Adelaide and Queen Elizabeth Hospital, Adelaide; Royal North Shore Hospital and University of Sydney, Sydney; Austin Hospital, Melbourne, Victoria; Alfred Hospital Melbourne, Victoria; Liverpool Hospital and University of New South Wales, Sydney, NSW; and Royal Perth Hospital and University of Western Australia, Perth, Australia; and Hamad Medical, Doha, Qatar.) Goal-directed resuscitation for patients with early septic shock. The ARISE Investigators and the ANZICS Clinical Trials Group. N Engl J Med 2014;3711496–506.