Internalisation of hepatitis C virus core protein by human conjunctival fibroblasts.
Indian J Med Microbiol
;
2016 Oct-Dec; 34(4): 536-538
Article
in English
| IMSEAR
| ID: sea-181126
ABSTRACT
Recent studies indicate that hepatitis C virus (HCV) proteins can mediate innate immune response and inflammation in conjunctival fibroblasts which contributes to the pathology of dry eye condition associated with chronic HCV infection. The present study investigates the phagocytic potential of human conjunctival fibroblasts (HCFj) for HCV core protein. HCFj cells were incubated with HCV core antigen for different periods of time, and fluorescent micrographs were taken to observe protein internalisation. HCFj cells were capable of internalising HCV core antigen within 1 h; this gives an insight into another molecular mechanism which may contribute towards HCV‑associated conjunctival inflammation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Journal:
Indian J Med Microbiol
Journal subject:
Microbiology
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS