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Oxidation as an important factor of protein damage: Implications for Maillard reaction.
J Biosci ; 2015 June; 40(2): 419-439
Article in English | IMSEAR | ID: sea-181409
ABSTRACT
Protein oxidation, the process caused especially by reactive oxygen and nitrogen species, is thought to play a major role in various oxidative processes within cells and is implicated in the development of many human diseases. This review provides a brief overview of the protein oxidation with the emphasis on the types of oxidation (oxidation of protein backbone and amino acid residues side chains, site-specific metal-catalysed protein oxidation), oxidationdependent generation of protein hydroperoxides, carbonyl derivatives and proteinprotein cross-linkages. Nonenzymatic glycoxidation (also known as Maillard reaction) as an important factor of protein damage, consequences of oxidative protein impairment and related diseases as well as means of monitoring and assessment of protein modifications are discussed.

Full text: Available Index: IMSEAR (South-East Asia) Language: English Journal: J Biosci Year: 2015 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Language: English Journal: J Biosci Year: 2015 Type: Article